Format

Send to

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2006 Jan 1;193(1):16-26. Epub 2005 Nov 22.

Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection.

Author information

1
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, USA.

Abstract

BACKGROUND:

Some individuals are readily infected with low human immunodeficiency virus type 1 (HIV-1) exposure, whereas others appear less susceptible, suggesting that host genetics plays a role in the viral entry pathway. The matched case-control study design with measured risk exposures provides an avenue for discovering genes involved in susceptibility to infection.

METHODS:

We conducted a nested case-control study of African Americans (266 HIV-1 seroconverter cases and 532 seronegative controls from the AIDS Link to Intravenous Experience cohort), to examine the association between 50 single-nucleotide polymorphisms (SNPs) in 9 candidate genes (CCR5, CCR2, RANTES, MIP1A, MCP2, IL10, IFNG, MCSF, and IL2) and susceptibility to HIV-1 infection. To account for differential exposure propensities, risk behavior self-reported during semiannual visits was used to estimate a standardized cumulative risk exposure (SCRE). Individual SNPs were evaluated using conditional logistic-regression models, and the inferred haplotypes were assessed in the haplotype trend regression analyses after adjusting for age and SCRE.

RESULTS:

Four SNPs (CCR2-V64I, CCR5-2459, MIP1A+954, and IL2+3896) and specific haplotypes in the IL2 and CCR2/CCR5 regions were significantly associated with HIV-1 infection susceptibility in different genetic models.

CONCLUSIONS:

Our results suggest that genetic variants in associated host genes may play an important role in susceptibility to HIV-1 infection.

PMID:
16323127
DOI:
10.1086/498532
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center