Format

Send to

Choose Destination
J Clin Invest. 2005 Dec;115(12):3406-8.

New ways in which GLP-1 can regulate glucose homeostasis.

Author information

1
Department of Medicine, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA.

Abstract

Glucagon-like peptide-1 (GLP-1) has a diverse set of peripheral actions which all serve to promote enhanced glucose tolerance, and for this reason it has become the basis for new treatments for type 2 diabetes. In this issue of the JCI, Knauf et al. provide clear evidence that GLP-1 signaling in the CNS is also linked to the control of peripheral glucose homeostasis by inhibiting non-insulin-mediated glucose uptake by muscle and increasing insulin secretion from the pancreas. The authors' work points to an important need to integrate diverse GLP-1 signaling actions and peripheral GLP-1 function in order to better understand both normal and abnormal glucose homeostasis.

PMID:
16322789
PMCID:
PMC1297270
DOI:
10.1172/JCI27207
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center