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Bioorg Med Chem Lett. 2006 Feb;16(3):737-42.

Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.

Author information

1
Division of Bio-Organic Science, Korea Research Institute of Chemical Technology, Daejeon 305-353, Republic of Korea.

Abstract

A series of dinaphtho[1,2-b;2',3'-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds with dialkylaminoethoxy group at C(5)-position (7, 8, 10, and 11) manifested strong inhibitory activities against epidermal growth factor receptor and vascular endothelial growth factor receptor. Docking study of 11 with EGFR was also performed.

PMID:
16321529
DOI:
10.1016/j.bmcl.2005.08.115
[Indexed for MEDLINE]

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