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J Perinatol. 2006 Jan 1;26(1):49-54.

Discharge outcomes of extremely low birth weight infants with spontaneous intestinal perforations.

Author information

1
Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908, and Department of Pediatrics, Carolinas Medical Center, Charlotte, NC, USA.

Abstract

OBJECTIVE:

To examine discharge outcomes of extremely low birth weight infants (ELBW) with spontaneous intestinal perforation (SIP).

STUDY DESIGN:

A single-center retrospective cohort study of all ELBW infants admitted to the University of Virginia neonatal intensive care unit between July 1996 and June 2004.

RESULTS:

We found 35 patients with SIP (incidence 8.4%). The median gestational age was 25 weeks, median birth weight was 722 g, and 71% of the infants were male. Most infants (n=28) with SIP were diagnosed secondary to pneumoperitoneum; however, one-third (7) of infants<25 weeks had occult presentations without pneumoperitoneum. When controlled for gestational age, gender, multiple gestation, indomethacin, and glucocorticoid exposure, infants with SIP have a higher risk of PVL and death than infants without perforation.

SUMMARY:

Periventricular leukomalacia and death are significantly associated with SIP in ELBW after adjusting for gestational age, multiple gestation, indomethacin, and glucocorticoid exposure.

PMID:
16319939
DOI:
10.1038/sj.jp.7211407
[Indexed for MEDLINE]

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