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J Neuropathol Exp Neurol. 2005 Dec;64(12):1029-36.

Mitogenic signal transduction pathways in meningiomas: novel targets for meningioma chemotherapy?

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1
Department of Pathology, University of Tennessee, Graduate School of Medicine, Knoxville, Tennessee 37920, USA. mdjohnso@mc.utmk.edu

Abstract

The roles of growth factor receptors and numerous downstream growth regulatory pathways are of increasing interest in neuro-oncology. These pathways have been extensively studied in gliomas but only recently analyzed in meningiomas. This article reviews current research on the growth factor receptor-Ras-Raf-1-MEK-1-MAPK, PI3K-Akt/PKB, PLC-gamma1-PKC, phospholipase A2-cyclooxygenase, and TGF-beta receptor-Smad pathways that appear to regulate meningioma growth and inhibit apoptosis. Sites along these receptor/kinase cascades that might be targeted by novel therapies are also discussed.

[Indexed for MEDLINE]

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