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J Neuropathol Exp Neurol. 2005 Dec;64(12):1029-36.

Mitogenic signal transduction pathways in meningiomas: novel targets for meningioma chemotherapy?

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Department of Pathology, University of Tennessee, Graduate School of Medicine, Knoxville, Tennessee 37920, USA.


The roles of growth factor receptors and numerous downstream growth regulatory pathways are of increasing interest in neuro-oncology. These pathways have been extensively studied in gliomas but only recently analyzed in meningiomas. This article reviews current research on the growth factor receptor-Ras-Raf-1-MEK-1-MAPK, PI3K-Akt/PKB, PLC-gamma1-PKC, phospholipase A2-cyclooxygenase, and TGF-beta receptor-Smad pathways that appear to regulate meningioma growth and inhibit apoptosis. Sites along these receptor/kinase cascades that might be targeted by novel therapies are also discussed.

[Indexed for MEDLINE]

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