Format

Send to

Choose Destination
Emerg Infect Dis. 2005 Oct;11(10):1503-6.

Antimicrobial drug resistance: "Prediction is very difficult, especially about the future".

Author information

1
Unité des Agents Antibactériens, Institut Pasteur, Paris, France. pcourval@pasteur.fr

Abstract

Evolution of bacteria towards resistance to antimicrobial drugs, including multidrug resistance, is unavoidable because it represents a particular aspect of the general evolution of bacteria that is unstoppable. Therefore, the only means of dealing with this situation is to delay the emergence and subsequent dissemination of resistant bacteria or resistance genes. Resistance to antimicrobial drugs in bacteria can result from mutations in housekeeping structural or regulatory genes. Alternatively, resistance can result from the horizontal acquisition of foreign genetic information. The 2 phenomena are not mutually exclusive and can be associated in the emergence and more efficient spread of resistance. This review discusses the predictable future of the relationship between antimicrobial drugs and bacteria.

PMID:
16318687
PMCID:
PMC3366764
DOI:
10.3201/eid1110.051014
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center