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Bioinformatics. 2006 Feb 1;22(3):356-8. Epub 2005 Nov 29.

Paircoil2: improved prediction of coiled coils from sequence.

Author information

1
Mathematics Department, Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA.

Abstract

We introduce Paircoil2, a new version of the Paircoil program, which uses pairwise residue probabilities to detect coiled-coil motifs in protein sequence data. Paircoil2 achieves 98% sensitivity and 97% specificity on known coiled coils in leave-family-out cross-validation. It also shows superior performance compared with published methods in tests on proteins of known structure.

PMID:
16317077
DOI:
10.1093/bioinformatics/bti797
[Indexed for MEDLINE]

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