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Gynecol Endocrinol. 2005 Oct;21(4):200-5.

BMI as a modifying factor in the relations between age at menarche, menstrual cycle characteristics, and risk of preeclampsia.

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1
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, 98122, USA. clb3@u.washington.edu

Abstract

To examine the relations between age at menarche and menstrual cycle characteristics and preeclampsia risk, we analyzed data from a case-control study conducted from 1998 to 2002. Usual menstrual cycle characteristics among 286 preeclampsia cases and 471 normotensive controls were assessed using a structured interview during postpartum hospitalization. We used multivariable logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), adjusting for confounders. We also examined the influence of pre-pregnancy body mass index (BMI) on selected hypothesized relations. Among lean women (pre-pregnancy BMI < 25 kg/m(2)), preeclampsia risk was lower in those reporting cycles > or = 36 days in length (adjusted OR 0.78, CI 0.35-1.83) and menarche at > or = 14 years (adjusted OR 0.48, 95% CI 0.28-0.82). In contrast, among overweight or obese women, preeclampsia risk was higher in those with long cycles (OR 3.11, 95% CI 0.62-1.56, p(interaction) = 0.16) and late menarche (OR 1.53, 95% CI 0.59-3.97, p(interaction) = 0.03). These data suggest that adiposity influences the relations between usual menstrual cycle length, age at menarche, and preeclampsia. Overweight women with long cycles are at particularly high preeclampsia risk.

PMID:
16316840
DOI:
10.1080/09513590500168431
[Indexed for MEDLINE]
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