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Clin Lab Sci. 2005 Fall;18(4):263-70.

Molecular-based laboratory testing and monitoring for human immunodeficiency virus infections.

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Clinical Immunology Laboratory, University of Maryland Medical Center, Baltimore, MD 21201-1192, USA.


Applications of laboratory testing for human immunodeficiency virus type 1 (HIV-1) infection have made significant impact on clinical care of HIV-infected patients globally. As these technologies continue to evolve and new technologies emerge, unique and highly sensitive nucleic acid-based testing methods will offer more and better means for us to guide physicians in anti-retroviral treatment strategies and clinical management of HIV infected patients. In this review we discuss a variety of current molecular-based methods that are available for HIV testing including diagnosis, monitoring disease progression, and detection of drug resistance to anti-retroviral therapy. Newer approaches that could be used in future HIV testing are also introduced.

[Indexed for MEDLINE]

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