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Anaesthesist. 2006 Mar;55(3):287-95.

[The GABA(A) receptor family: possibilities for the development of better anesthetics].

[Article in German]

Author information

1
Abteilung für Anaesthesiologie und Intensivmedizin, Universitätsklinikum, Tübingen. berthold.drexler@uni-tuebingen.de

Abstract

Clinically used anesthetics show amnestic, sedative, hypnotic and immobilizing properties. On a molecular level these drugs affect several receptors in the cell membrane of neurons. By using genetically engineered mice a linkage can now be made between actions on certain receptors and clinically desired and undesired effects. Experiments show that a certain GABA(A) receptor subtype mediates hypnosis and immobility, whereas another subtype is involved in side-effects like sedation and hypothermia. These findings form the basis for the development of new drugs, acting highly specific and with fewer side-effects.

PMID:
16315024
DOI:
10.1007/s00101-005-0950-y
[Indexed for MEDLINE]

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