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Nat Rev Mol Cell Biol. 2005 Oct;6(10):801-11.

Tetraspanin functions and associated microdomains.

Author information

1
Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA. Martin_Hemler@dfci.harvard.edu

Abstract

Cell-surface proteins of the tetraspanin family are small, and often hidden by a canopy of tall glycoprotein neighbours in the cell membrane. Consequently, tetraspanins have been understudied and underappreciated, despite their presence on nearly all cell and tissue types. Important new genetic evidence has now emerged, and is bolstered by new insights into the cell biology, signalling and biochemistry of tetraspanins. These new findings provide a framework for better understanding of these mysterious molecules in the regulation of cellular processes, from signalling to motility.

PMID:
16314869
DOI:
10.1038/nrm1736
[Indexed for MEDLINE]

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