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J Cell Biol. 2005 Dec 5;171(5):761-3. Epub 2005 Nov 28.

Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin.

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1
Department of Medicine, Northwestern University, Chicago, IL 60637, USA.

Abstract

Nuclear targeting of beta-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes beta-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of beta-catenin. We speculate that cells may use multiple export mechanisms to inhibit beta-catenin signaling in different ways.

PMID:
16314432
PMCID:
PMC2171287
DOI:
10.1083/jcb.200510127
[Indexed for MEDLINE]
Free PMC Article
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