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Nat Prod Rep. 2005 Dec;22(6):696-716. Epub 2005 Nov 2.

An update on bioactive plant lignans.

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1
Medicinal Chemistry Research Center, Division of Life Sciences, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea.

Abstract

Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C6-C3) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities, and comprises the data reported in more than 100 peer-reviewed articles, so as to highlight the recently reported bioactive lignans that could be a first step towards the development of potential new therapeutic agents.

PMID:
16311631
DOI:
10.1039/b514045p
[Indexed for MEDLINE]
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