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Nat Med. 2005 Dec;11(12):1295-8. Epub 2005 Nov 27.

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.

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1
[1] Department of Surgery, University of Western Ontario, London, Ontario N6A 5C1, Canada.

Abstract

We transplanted kidneys from alpha1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.

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PMID:
16311604
PMCID:
PMC3018862
DOI:
10.1038/nm1330
[Indexed for MEDLINE]
Free PMC Article

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