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Trends Immunol. 2006 Jan;27(1):1-4. Epub 2005 Nov 23.

CARD games between virus and host get a new player.

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Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.


A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAVS, VISA and Cardif, which is an essential signaling adaptor of the host defense mediating CARD-CARD interactions with retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDAS), sensors of virus infection. Disruption of this novel signaling pathway by hepatitis C virus (HCV) might provide a foundation for viral persistence.

[Indexed for MEDLINE]

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