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Methods. 2005 Nov;37(3):247-60.

A microarray data analysis framework for postmortem tissues.

Author information

1
Signal Processing Laboratory, Department of Engineering, University of Cambridge, UK.

Abstract

This paper will give a complete methodological approach to the processing of oligonucleotide microarray data from postmortem tissue, particularly brain matter. Attention will be drawn to each of the important stages in the process; specifically the quality control, gene expression value calculation, multiple hypothesis testing and correlation analyses. We shall initially discuss the theoretical foundations of each individual method and subsequently apply the ensemble to a sample data set to illustrate and visualise important points.

PMID:
16308154
DOI:
10.1016/j.ymeth.2005.09.006
[Indexed for MEDLINE]

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