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Mol Cell. 2005 Nov 23;20(4):499-501.

Dephosphorylation shows SR proteins the way out.

Author information

1
Molecular Genetics, Department of Biomedical Sciences, School of Public Health, Ge*NY*Sis Center for Excellence in Cancer Genomics, 1 Discovery Drive, Room 220, Rensselaer, New York 12144, USA.

Abstract

To address the role of the RS domain in shuttling and how it is differentially required for constitutive and alternative splicing, Lin et al. (2005 [in the November 11 issue of Molecular Cell]) employ an elegant somatic complementation system to reveal a novel phosphorylation-dependent mechanism regulating distinct recycling pathways for SR proteins during mRNP maturation.

PMID:
16307914
PMCID:
PMC2517054
DOI:
10.1016/j.molcel.2005.11.005
[Indexed for MEDLINE]
Free PMC Article

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