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Virus Res. 2006 Jul;119(1):43-51. Epub 2005 Nov 22.

End-to-end communication in the modulation of translation by mammalian RNA viruses.

Author information

1
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.

Abstract

A 5'-3' end interaction leading to stimulation of translation has been described for many cellular and viral mRNAs. Enhancement of viral translational efficiency mediated by 5' and 3' untranslated regions (UTRs) has been shown to occur via RNA-RNA interactions or novel RNA-protein interactions. Mammalian RNA viruses make use of end-to-end communication in conjunction with both viral and cellular factors to regulate multiple processes including translation initiation and the switch between translation and RNA synthesis during the viral lifecycle.

PMID:
16307817
DOI:
10.1016/j.virusres.2005.10.012
[Indexed for MEDLINE]

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