Format

Send to

Choose Destination
J Geriatr Psychiatry Neurol. 2005 Dec;18(4):218-23.

Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression.

Author information

1
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612-3899, USA. jmortime@hsc.usf.edu

Abstract

Numerous studies show that the pathology of Alzheimer's disease is present decades before a clinical diagnosis of dementia can be made. Given the likelihood that agents will become available that reliably delay onset and/or slow progression of Alzheimer's disease, it will be important to detect preclinical Alzheimer's disease as early as possible for maximal treatment effect. Detection of individuals by sensitive cognitive measures provides one way to identify people who are at high risk of developing clinical Alzheimer's disease. However, it is likely that those with considerable brain or cognitive reserve will be able to mask cognitive deficits until very close to the onset of the dementia, rendering such cognitive measures insensitive. Optimum biomarkers for Alzheimer's disease therefore need to target the severity of underlying brain pathology independently of brain reserve. Findings are presented showing the importance of higher education and larger brain size in masking the underlying disease pathology.

PMID:
16306243
PMCID:
PMC1405917
DOI:
10.1177/0891988705281869
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center