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Chemistry. 2006 Apr 12;12(12):3194-200.

Ir-catalysed asymmetric hydrogenation: Ligands, substrates and mechanism.

Author information

1
Uppsala Universitet, Avd. f. Organisk Kemi, Kemiska Institutionen, Box 559, 751 24 Uppsala, Sweden.

Abstract

Relatively air and moisture tolerant cationic iridium complexes, with chiral non-racemic N,P-ligands and weakly coordinating counter ions, are efficient catalysts in the asymmetric hydrogenation of olefins. Unfunctionalised olefins are particularly difficult substrates because, in general, a polar group adjacent to the alkene bond is required for high catalytic activity and enantioselectivity. The applicability towards a variety of substrates and choice of ligands reported thus far in the literature, as well as the mechanism, selectivity issues and the importance of the anion are also discussed.

PMID:
16304642
DOI:
10.1002/chem.200500755

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