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MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management.

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1
Mayo Clinic College of Medicine, Division of Hematology, 200 First Avenue St., SW, Rochester, MN 55905, USA. rajks@mayo.edu

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic, pre-malignant disorders characterized by monoclonal plasma cell proliferation in the bone marrow and absence of end-organ damage. Recent advances in the pathogenesis, natural history, and prognosis of MGUS and SMM are reviewed. A new risk stratification system to determine the prognosis of MGUS using the size and type of M protein, and the serum free light chain assay is discussed.

PMID:
16304401
DOI:
10.1182/asheducation-2005.1.340
[Indexed for MEDLINE]
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