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Antimicrob Agents Chemother. 2005 Dec;49(12):5160-1.

A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.

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1
Department of Clinical Sciences, Cornell University School of Veterinary Medicine, Ithaca, New York 14850, USA.

Abstract

Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi, as documented by histopathological lesion scores and serum troponin I levels.

PMID:
16304193
PMCID:
PMC1315979
DOI:
10.1128/AAC.49.12.5160-5161.2005
[Indexed for MEDLINE]
Free PMC Article
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