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Antimicrob Agents Chemother. 2005 Dec;49(12):5127-8.

Pitfalls in estimating piperaquine elimination.

Author information

1
Department of Pharmacology, Göteborg University, Sweden.

Abstract

By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.

PMID:
16304183
PMCID:
PMC1315981
DOI:
10.1128/AAC.49.12.5127-5128.2005
[Indexed for MEDLINE]
Free PMC Article

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