Format

Send to

Choose Destination
Cancer Lett. 2006 Sep 8;241(1):13-22. Epub 2005 Nov 21.

Translesion DNA replication proteins as molecular targets for cancer prevention.

Author information

1
Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.

Abstract

Mutations in DNA are generally considered to have an etiologic role in the development of cancer. If so, it follows that reducing the frequency of such mutations will reduce the incidence of cancer induced by mutagens. Recent advances in elucidating the molecular mechanisms of carcinogen-induced mutagenesis indicate that replication of DNA templates that contain replication-blocking adducts is accomplished with error-prone DNA polymerases. These polymerases have relaxed base-pairing requirements, and can insert bases across from adducted templates, but with potentially mutagenic consequences. In principle, these proteins present new and attractive molecular targets to reduce mutagenesis. If this can be done in vivo without increasing cytotoxic responses to carcinogens, then novel chemopreventive strategies can be designed to reduce the risk of cancer in exposed populations prior to the appearance of disease symptoms.

PMID:
16303242
DOI:
10.1016/j.canlet.2005.10.013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center