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Semin Vasc Med. 2005 Nov;5(4):321-7.

The harmonization of quantitative test results of different D-dimer methods.

Author information

1
ECAT Foundation, Gaubius Laboratory, Leiden, The Netherlands.

Abstract

Nowadays D-dimer testing is frequently applied in the diagnosis of venous thromboembolism. However, the test results of different quantitative D-dimer tests can differ significantly. The background of this variability, which is mainly caused by the variety of fibrin degradation products in plasma, the specificity of D-dimer assays, and the calibrators used in the test, is summarized here. Because D-dimer is not a single entity in plasma but a mixture of heterogeneous fibrin degradation products, method standardization is in principle impossible. Efforts undertaken in the past to standardize D-dimer methods are summarized. All these projects failed and it was concluded that only harmonization of D-dimer test results seems to be feasible. The results of a large field study on which a new approach to the harmonization of quantitative D-dimer methods will be based is summarized in this article. This approach seems to be an adequate solution for overcoming the practical problem of variation of test outcome in different D-dimer assays.

PMID:
16302153
DOI:
10.1055/s-2005-922477
[Indexed for MEDLINE]

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