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Neurology. 2005 Nov 22;65(10):1636-8.

Similar brain tau pathology in DM2/PROMM and DM1/Steinert disease.

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1
INSERM U422, Faculté de Médecine, Lille, France. ca-maurage@chru-lille.fr

Abstract

Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS of a patient with DM2 and compare it to that of patients with DM1. A reduced expression of tau exon 2 and exon 3 epitopes is observed in both DM1 and DM2. This suggests a similar physiopathologic process that may contribute to common neurologic features in patients with DM.

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