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Neuron. 2005 Nov 23;48(4):535-8.

Searching for "the top" in top-down control.

Author information

1
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA. btmiller@berkeley.edu

Abstract

Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive due to methodological challenges in tracking the spatiotemporal dynamics of cortical networks. However, we discuss several promising approaches that could further our understanding of the role of the PFC in goal-directed behavior.

PMID:
16301170
DOI:
10.1016/j.neuron.2005.11.002
[Indexed for MEDLINE]
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