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J Med Virol. 2006 Jan;78(1):1-8.

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.

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The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA.


Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.

[Indexed for MEDLINE]

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