Abstract
We report here invasin-dependent and invasin-independent mechanisms in which the enteropathogen Yersinia enterocolitica is able to disseminate from the lumen of the small intestine to the spleen. The invasin-dependent route is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adhesins, Bacterial / metabolism*
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Animals
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Immunity / genetics
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Intestine, Small / microbiology
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Lymph Nodes / immunology
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Mice
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Mice, Mutant Strains
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Peyer's Patches / immunology
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Peyer's Patches / microbiology
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Spleen / microbiology
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Yersinia Infections / immunology
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Yersinia Infections / microbiology*
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Yersinia enterocolitica / metabolism
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Yersinia enterocolitica / pathogenicity*
Substances
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Adhesins, Bacterial
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invasin, Yersinia