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Int J Oral Maxillofac Surg. 2006 Apr;35(4):362-5. Epub 2005 Nov 18.

Detection of p16 promoter methylation in the serum of oral cancer patients.

Author information

1
Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Ehime, Japan.

Abstract

P16 promoter methylation occurs frequently in oral squamous cell carcinoma (OSCC). For the early detection of tumour-related aberrant DNA, we examined p16 methylation using the methylation-specific polymerase chain reaction (MSP) in tumour and serum samples of 17 OSCC patients. Aberrant p16 methylation was detected in 11 (64.7%) cases of primary OSCC. Of these 11 patients, 6 (54.5%) showed the same alteration in their serum. No methylation was found in control groups. Interestingly, DNA was detected in the serum of 3 out of 4 patients with recurrence. These results suggest that the MSP may be a sensitive and useful method for detecting recurrent OSCC.

PMID:
16298513
DOI:
10.1016/j.ijom.2005.08.005
[Indexed for MEDLINE]

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