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Trends Cardiovasc Med. 2005 Nov;15(8):302-8.

Regulation of Weibel-Palade body exocytosis.

Author information

1
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. clowenst@jhmi.edu

Abstract

Weibel-Palade bodies (WPBs) are endothelial granules that store von Willebrand factor (VWF), P-selectin, and other vascular modulators. Endothelial cells secrete WPBs in response to vascular injury, releasing VWF, which triggers platelet rolling, and externalizing P-selectin, which activates leukocyte trafficking. Endothelial exocytosis is one of the earliest responses to vascular damage and plays a pivotal role in thrombosis and inflammation. This review examines the regulation of WPB exocytosis-the exocytic machinery, activators, and inhibitors of exocytosis-and speculates about the development of novel anti-exocytic drugs.

PMID:
16297768
DOI:
10.1016/j.tcm.2005.09.005
[Indexed for MEDLINE]

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