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Trends Immunol. 2006 Jan;27(1):11-6. Epub 2005 Nov 16.

Have we cut ourselves too short in mapping CTL epitopes?

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Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Qld 4029, Australia.


MHC class I molecules generally present peptides of eight to ten amino acids; however, peptides of 11-14 residues can also elicit dominant cytotoxic T lymphocyte responses, sometimes at the expense of overlapping shorter peptides. Although long-bulged epitopes are considered to represent a barrier for T cell receptor recognition, recent structural data reveal how these super-bulged peptides are engaged while simultaneously maintaining MHC restriction. We propose that algorithms widely used to predict class I-binding peptides should now be broadened to include peptides of over ten residues in length.

[Indexed for MEDLINE]

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