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Clin Nutr. 2005 Dec;24(6):979-87. Epub 2005 Nov 15.

Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial.

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1
Department of Nutrition and Dietetics, Austin Health, Studley Road, Heidelberg 3084, and School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia.

Abstract

BACKGROUND & AIMS:

Nutrients putatively implicated in pressure ulcer healing were evaluated in a clinical setting.

METHODS:

Sixteen inpatients with a stage 2, 3 or 4 pressure ulcer randomised to receive daily a standard hospital diet; a standard diet plus two high-protein/energy supplements; or a standard diet plus two high-protein/energy supplements containing additional arginine (9 g), vitamin C (500 mg) and zinc (30 mg). Nutritional status measurements (dietary, anthropometric and biochemical) and pressure ulcer size and severity (by PUSH tool; Pressure Ulcer Scale for Healing; 0=completely healed, 17=greatest severity) were measured weekly for 3 weeks.

RESULTS:

Patients' age and BMI ranges were 37-92 years and 16.4-28.1 k g/m2) respectively. Baseline PUSH scores were similar between groups (8.7+/-0.5). Only patients receiving additional arginine, vitamin C and zinc demonstrated a clinically significant improvement in pressure ulcer healing (9.4+/-1.2 vs. 2.6+/-0.6; baseline and week 3, respectively; P<0.01). All patient groups presented with low serum albumin and zinc and elevated C-reactive protein. There were no significant changes in biochemical markers, oral dietary intake or weight in any group.

CONCLUSIONS:

In this small set of patients, supplementary arginine, vitamin C and zinc significantly improved the rate of pressure ulcer healing. The results need to be confirmed in a larger study.

PMID:
16297506
DOI:
10.1016/j.clnu.2005.06.011
[Indexed for MEDLINE]
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