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Clin Exp Immunol. 2005 Dec;142(3):454-60.

Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens.

Author information

1
Department of Medical Biochemistry and Immunology, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, UK. BoulterJM@Cardiff.ac.uk

Abstract

The recent development of T cell receptor phage display opens up the possibility of engineering human T cell receptors with antibody-like binding properties for cell-surface peptide antigens. In this review we briefly discuss recent developments in molecular targeting of peptide antigens. We then discuss potential clinical applications of engineered high-affinity T cell receptors in autoimmunity and cancer.

PMID:
16297157
PMCID:
PMC1809535
DOI:
10.1111/j.1365-2249.2005.02929.x
[Indexed for MEDLINE]
Free PMC Article
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