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Equine Vet J. 2005 Nov;37(6):559-64.

Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anaesthesia in horses.

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1
Department of Large Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA.

Abstract

REASONS FOR PERFORMING STUDY:

Lidocaine constant rate infusions (CRIs) are common as an intraoperative adjunct to general anaesthesia, but their influence on quality of recovery has not been thoroughly determined.

OBJECTIVES:

To determine the effects of an intraoperative i.v. CRI of lidocaine on the quality of recovery from isoflurane or sevoflurane anaesthesia in horses undergoing various surgical procedures, using a modified recovery score system.

HYPOTHESIS:

The administration of intraoperative lidocaine CRI decreases the quality of recovery in horses.

METHODS:

Lidocaine (2 mg/kg bwt bolus followed by 50 microg/kg bwt/min) or saline was administered for the duration of surgery or until 30 mins before the end of surgery under isoflurane (n = 27) and sevoflurane (n = 27).

RESULTS:

Horses receiving lidocaine until the end of surgery had a significantly higher degree of ataxia and a tendency towards significance for a lower quality of recovery. There was no correlation between lidocaine plasma concentrations at recovery and the quality of recovery.

CONCLUSIONS:

Intraoperative CRI of lidocaine affects the degree of ataxia and may decrease the quality of recovery.

POTENTIAL RELEVANCE:

Discontinuing lidocaine CRI 30 mins before the end of surgery is recommended to reduce ataxia during the recovery period.

PMID:
16295936
[Indexed for MEDLINE]
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