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J Org Chem. 2005 Nov 25;70(24):10210-2.

IBX-mediated alpha-hydroxylation of alpha-alkynyl carbonyl systems. A convenient method for the synthesis of tertiary alcohols.

Author information

  • 1Department Chemie, Technische Universit√§t M√ľnchen, Lichtenbergstr. 4, D-85747 Garching, Germany. stefan.kirsch@ch.tum.de

Abstract

[reaction: see text] IBX (o-iodoxybenzoic acid) is an excellent reagent for the alpha-hydroxylation of alpha-alkynyl carbonyl compounds without giving dehydrogenation products. The convenient procedure proves to be useful for the construction of a variety of tertiary alcohols (55-91%) under mildly acidic conditions.

PMID:
16292876
DOI:
10.1021/jo051898j
[PubMed]
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