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Neurochirurgie. 2005 Sep;51(3-4 Pt 2):309-22.

[Metabolic imaging for supratentorial oligodendrogliomas].

[Article in French]

Author information

1
CHU et GIP Cyceron, Caen. derlon-jm@chu-caen.fr

Abstract

Metabolic imaging with positron emission tomography (PET) provides, in neuro-oncology, information complementary to that provided by anatomic imaging obtained with CT-scanner or MRI. Only a few publications have yet reported its use in oligodendroglial tumors. These findings and partial results obtained in ongoing work, suggest some preliminary conclusions: 11C-MET (L-methyl-methionine) is a more appropriate tracer than 18F-FDG (fluoro-deoxy-glucose), in terms of both specificity and sensitivity, for the assessment of patients with this category of tumor. PET/MET allows differentiation between grade II and grade III oligodendrogliomas; better targeting for stereotactic biopsy; more accurate assessment of the post-operative residual tumor; identification of progression from low-grade to anaplastic grade during the disease course; differentiation between recurrence and a post-radiation processes. PET/MET allows, to some extent, prediction of response to radiotherapy; and, probably, to chemotherapy.

PMID:
16292175
DOI:
10.1016/s0028-3770(05)83492-7
[Indexed for MEDLINE]

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