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J Bacteriol. 1992 Aug;174(15):5141-4.

A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens.

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1
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.

Abstract

The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene.

PMID:
1629172
PMCID:
PMC206334
[Indexed for MEDLINE]
Free PMC Article
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