Abstract
Paecilomyces variotii, an emerging hyalohyphomycetes, has been reported to be susceptible in vitro to voriconazole. We describe a case of disseminated P. variotii infection in a neutropenic child with relapsed leukaemia who was on voriconazole prophylaxis. The P. variotii isolate was resistant to voriconazole in vitro. The patient responded to liposomal amphotericin B.
MeSH terms
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Adolescent
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Amphotericin B / pharmacology
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Amphotericin B / therapeutic use*
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use*
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Dermatomycoses / drug therapy
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Dermatomycoses / microbiology
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Drug Resistance, Fungal
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Fungemia / drug therapy
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Fungemia / microbiology
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Humans
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Lung Diseases, Fungal / drug therapy
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Lung Diseases, Fungal / microbiology
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Male
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Microbial Sensitivity Tests
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Mycoses / diagnostic imaging
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Mycoses / drug therapy*
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Mycoses / prevention & control
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Neutropenia / complications
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Neutropenia / drug therapy
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Paecilomyces / drug effects*
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Paecilomyces / isolation & purification
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Pyrimidines / pharmacology
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Pyrimidines / therapeutic use*
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Radiography
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Treatment Outcome
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Triazoles / pharmacology
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Triazoles / therapeutic use*
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Voriconazole
Substances
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Antifungal Agents
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Pyrimidines
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Triazoles
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Amphotericin B
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Voriconazole