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Bioorg Med Chem Lett. 2006 Feb;16(3):490-4. Epub 2005 Nov 11.

Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: 1H-pyrimidin-2-one derivatives.

Author information

1
Abbott GmbH & Co. KG, Discovery Research, D-67008 Ludwigshafen, Germany. herve.geneste@abbott.com

Abstract

The synthesis and SAR of novel highly potent and selective dopamine D(3)-receptor antagonists based on a 1H-pyrimidin-2-one scaffold are described. A-690344 antagonized PD 128907-induced huddling deficits in rat (ED(50) 6.1mg/kg po), a social interaction paradigm.

PMID:
16290141
DOI:
10.1016/j.bmcl.2005.10.068
[Indexed for MEDLINE]

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