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Vision Res. 2006 Mar;46(5):688-98. Epub 2005 Nov 14.

Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice.

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Institut fuer Klinische Physiologie, Charite-Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany.


We studied electrophysiological properties of cultured retinal pigment epithelial (RPE) cells from mouse and a mouse model for Norrie disease. Wild-type RPE cells revealed the expression of ion channels known from other species: delayed-rectifier K(+) channels composed of Kv1.3 subunits, inward rectifier K(+) channels, Ca(V)1.3 L-type Ca(2+) channels and outwardly rectifying Cl(-) channels. Expression pattern and the ion channel characteristics current density, blocker sensitivity, kinetics and voltage-dependence were compared in cells from wild-type and Norrie mice. Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models.

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