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Phytochemistry. 2005 Dec;66(24):2844-50. Epub 2005 Nov 11.

Cytotoxic clerodane diterpenes from Glossocarya calcicola.

Author information

1
Centre for Phytochemistry and Pharmacology, Southern Cross University, Military Rd., Level 2, Lismore, N.S.W. 2780, Australia. hrasik10@scu.edu.au

Abstract

Three clerodane diterpenes were isolated and identified from leaf extract of Glossocarya calcicola. Compound has been characterised as (rel)-10betaH-trans-12xi-(2-methylbut-2(E)-enoyl)-1beta-(isobutanoyl)-6alpha,13xi-dihydroxyclerodan-4(20),8(18)-dien-7,15-dione-15,16-oxide, to which we have assigned the trivial name calcicolin-A. The other two compounds had the same skeletal structure and C-12 substituent but in compound, the C-1 esterifying group becomes 2-methylbut-2(E)-enoic acid and in it becomes 2-methylbutanoic acid. Although anti-insect activity was not observed for G. calcicola, cytotoxicity against insect and human carcinoma cell lines was detected.

PMID:
16289257
DOI:
10.1016/j.phytochem.2005.09.024
[Indexed for MEDLINE]

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