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Trans R Soc Trop Med Hyg. 2006 Feb;100(2):184-6. Epub 2005 Nov 10.

Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations.

Author information

1
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. paul@tropmedres.ac

Abstract

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.

PMID:
16289166
DOI:
10.1016/j.trstmh.2005.01.008
[Indexed for MEDLINE]

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