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Oncogene. 2005 Nov 14;24(50):7465-74.

Akt-regulated pathways in prostate cancer.

Author information

1
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA.

Abstract

Prostate cancer remains a major cause of cancer-related mortality. Genetic clues to the molecular pathways driving the most aggressive forms of prostate cancer have been limited. Genetic inactivation of PTEN through either gene deletion or point mutation is reasonably common in metastatic prostate cancer and the resulting activation of phosphoinostide 3-kinase, AKT and mTOR provides a major therapeutic opportunity in this disease as mTOR inhibitors, HSP90 inhibitors and PI3K inhibitors begin to enter clinical development.

PMID:
16288293
DOI:
10.1038/sj.onc.1209096
[Indexed for MEDLINE]

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