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Nat Neurosci. 2005 Dec;8(12):1657-9. Epub 2005 Nov 13.

NMDA receptor-independent long-term depression correlates with successful aging in rats.

Author information

1
Department of Neuroscience, The Mind/Brain Institute, Baltimore, Maryland 21218, USA.

Abstract

Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.

PMID:
16286930
DOI:
10.1038/nn1586
[Indexed for MEDLINE]

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