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Horm Res. 2005;64 Suppl 2:6-11.

A nationwide attempt to standardize growth hormone assays.

Author information

1
The GH and Its Related Factors Study Committee, The Foundation for Growth Science, Tokyo, Japan. tanaka-t@ncchd.go.jp

Abstract

The Growth Hormone (GH) and Its Related Factors Study Committee of the Foundation for Growth Science, Japan, has been conducting a quality control study for 15 years to improve the equality of diagnosis of GH deficiency. It found that the greatest differences in measured GH values were due to the different potencies of the kit standards, which were primarily adjusted to WHO standards for human GH of pituitary origin. With the collaboration of kit makers and the Study Group of Hypothalamo-Pituitary Disorders of the Ministry of Health, Labor and Welfare, all GH kits in Japan have begun using the same recombinant human GH standard since April 2005. As a result the diagnostic cut-off peak GH has changed from 10 to 6 ng/ml.

PMID:
16286763
DOI:
10.1159/000087746
[Indexed for MEDLINE]

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