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Cancer Cell. 2005 Nov;8(5):349-50.

The dual adverse effects of TGF-beta secretion on tumor progression.

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1
Cancer Immunology Program, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, 3002, Australia. joe.trapani@petermac.org

Abstract

When a cancer escapes the growth-inhibitory effects of TGF-beta secreted by cancer cells themselves or by cells in the local stroma, a further adverse outcome for the host is the associated TGF-beta-induced suppression of anticancer T cell immunity. In addition to the previously described dampening of T cell activation and proliferation, TGF-beta markedly and directly suppresses the transcription of genes encoding multiple key proteins of the "cytotoxic program" of CD8+ CTL, such as perforin and granzymes, cytotoxins that act through the granule exocytosis pathway. The findings described below suggest that TGF-beta and its signaling pathways will be major targets for novel cancer therapeutics.

PMID:
16286241
DOI:
10.1016/j.ccr.2005.10.018
[Indexed for MEDLINE]
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