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J Neuropsychiatry Clin Neurosci. 1992 Spring;4(2):134-9.

Reliability, validity, and clinical correlates of apathy in Parkinson's disease.

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Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.


The authors examined a consecutive series of 50 patients for the presence of apathy, depression, anxiety, and neuropsychological deficits using a neuropsychological battery that included a recently designed apathy scale. This scale was found to be reliable and valid in the diagnosis of apathy in patients with PD. Of patients in the study, 12% showed apathy as their primary psychiatric problem, and 30% were both apathetic and depressed. Patients with apathy (with or without depression), showed significantly more deficits in both tasks of verbal memory and time-dependent tasks. Results suggest that apathy is a frequent finding in PD, is significantly associated with specific cognitive impairments, and may have a different mechanism than depression.

[Indexed for MEDLINE]

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