Format

Send to

Choose Destination
Acta Paediatr. 2005 Sep;94(9):1227-31.

Autonomic nervous system functions in children with breath-holding spells and effects of iron deficiency.

Author information

1
Ankara University, Medical School, Department of Paediatric Cardiology, Ankara, Turkey.

Abstract

AIM:

To analyse the activity of the autonomic nervous system during breath-holding spells, we assessed the ECG changes, including ventricular repolarization parameters before and during the spell. We also analysed the effects of iron deficiency on these ECG parameters.

METHODS:

The study group consisted of 37 children with breath-holding spells (30 cyanotic, 7 pallid) (mean age+/-SD: 12.9+/-10.8 mo). Twenty-six healthy children (mean age+/-SD: 14.4+/-8.6 mo) served as a control group. All patients and controls had standard 12-lead simultaneous surface ECG. All patients had ECG recordings during at least one severe breath-holding spell obtained by "event recorder". Traces obtained by "event recorder" were analysed in terms of mean heart rate and the frequency and duration of asystole during the spell.

RESULTS:

Respiratory sinus arrhythmia on standard ECGs and asystole frequency during spells were higher in patients with pallid breath-holding spells. Patients with iron deficiency had a lower frequency of respiratory sinus arrhythmia and prolonged asystole time during the spell. There was no difference in terms of ventricular repolarization parameters (QT/QTc intervals and QT/QTc dispersions) between patients and controls and between patient subgroups (cyanotic versus pallid).

CONCLUSION:

These results confirmed the presence of autonomic dysregulation in children with breath-holding spells. Iron deficiency may have an impact on this autonomic dysregulation. Ventricular repolarization was unaffected in patients with breath-holding spells.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center