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J Biol Chem. 2006 Jan 13;281(2):1073-9. Epub 2005 Nov 8.

Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine.

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Gladstone Institute of Cardiovascular Disease and Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.


Apolipoprotein (apo)E plays a critical role in cholesterol transport, through high affinity binding to the low density lipoprotein receptor. This interaction requires apoE to be associated with a lipoprotein particle. To determine the structure of biologically active apoE on a lipoprotein particle, we crystallized dipalmitoylphosphatidylcholine particles containing two apoE molecules and determined the molecular envelope of apoE at 10 Angstroms resolution. On the basis of the molecular envelope and supporting biochemical evidence, we propose a model in which each apoE molecule is folded into a helical hairpin with the binding region for the low density lipoprotein receptor at its apex.

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